Effect of Metformin on pathological indices related to cardiovascular disease in diabetes

This study investigates the effect of metformin, the widely known oral hypoglycemic agent, regarding its several common pathological indices often responsible in case of Cardio Vascular Disorder (CVD) within most of the diabetic patients. Those enrolled in the study were randomized providing metformin and placebo for a period of 24 weeks. The production of Reactive oxygen species (ROS) as well as mitochondrial membrane hyperpolarization was noticeably decreased whereas nitric oxide production was restored in case of diabetics treated with the metformin. The level of Homo-cysteine was seemingly higher after treating with metformin (16.97+5.63 vs 15.85+5.35µmol/l) but not enough significant (p=0.067). On the other hand vitamin B12 level was greatly reduced in those treated with the metformin compared to placebo controlled counterpart (p=0.001). The observation emphasizes the possibility of lowering CVDs among the Type 2 diabetes mellitus (T2DM) patients after treating 24 weeks with the Metformin