Involvement of CD11b+ GR-1low cells in autoimmune disorder in MRL-Faslpr mouse

Yasunori Iwata,Kengo Furuichi,Kiyoki Kitagawa,Akinori Hara,Toshiya Okumura,Satoshi Kokubo,Kazuaki Shimizu,Norihiko Sakai,Akihiro Sagara,Yukie Kurokawa,Satoshi Ueha,Kouji Matsushima,Shuichi Kaneko,Takashi Wada

Involvement of CD11b+ GR-1low cells in autoimmune disorder in MRL-Faslpr mouse

2010

Yasunori Iwata
Kengo Furuichi
Kiyoki Kitagawa
Akinori Hara
Toshiya Okumura
Satoshi Kokubo
Kazuaki Shimizu
Norihiko Sakai
Akihiro Sagara
Yukie Kurokawa
Satoshi Ueha
Kouji Matsushima
Shuichi Kaneko
Takashi Wada

Objective Myeloid-derived suppressor cells (MDSCs) have been identified as immunosuppressive cells in tumor-related inflammation. However, the pathogenesis of MDSCs for autoimmune disease has not been investigated as yet. The aim of this study was to address whether MDSCs contribute to autoimmune organ injury in lupus-prone mice.

Keywords:

CCR2
Inflammation
Endocrinology
Internal medicine
Pathogenesis
Autoimmune disease
Diabetes mellitus
Immunology
Kidney
Medicine
Integrin alpha M
Nephrology

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