Abstract LB-359: Gene expression profile and tumor infiltrating lymphocytes in Hispanic women with breast cancer

Breast cancer (BC) is the most commonly diagnosed cancer among women and is currently classified into four molecular subtypes. These subtypes have been characterized by their distinct immune gene profiles, where only triple-negative (TN) and HER2+ subtypes are recognized for being tumor immunogenic cancers. The main objective of this pilot study is to understand whether the immune gene expression profile from breast tumors can be associated with tumor infiltrating lymphocytes (TILs) levels in Hispanic women. Breast tumors were obtained through the Puerto Rico Biobank at Ponce Health Sciences University and in collaboration with Moffitt Cancer Center. Pathology reports were also obtained to collect information about tumor characteristics and molecular subtype classification. Fresh frozen (FF) (n=40) and FFPE (n=27) breast tumors were cut into slide sections and stained with HE 2020 Apr 27-28 and Jun 22-24. Philadelphia (PA): AACR; Cancer Res 2020;80(16 Suppl):Abstract nr LB-359.