CGG repeat DNA assisted dimerization of CGG/CGG binding molecule through intermolecular disulfide formation

A new DNA binding small molecule, NCD-CC is reported. NCD-CC has a NCD domain, which recognizes the G–G mismatch in a CGG/CGG triad, and a cysteinylcystein (CC) moiety. Dimerization of NCD-CC through intermolecular disulfide bond formation was accelerated in the presence of CGG repeat DNA.