Immune molecular profiling of a multiresistant primary prostate cancer with a neuroendocrine-like phenotype

Understanding the drivers of recurrence in aggressive prostate cancers requires detailed molecu-lar and genomic understanding in order to aid therapeutic interventions. Here we present a case study of a 70 year old male with high-grade clinically-localised acinar adenocarcinoma treated with definitive hormone therapy and radiotherapy. The patient progressed rapidly with rising PSA and succumbed without metastasis 52 months after diagnosis. We provide here a descrip-tion of histological, transcriptional, proteomic, immunological, and genomic features associated with this disease - identifying hallmarks of canonical neuroendocrine PC disease and other nov-el molecular features.