Effect of pseudoephedrine on 800-m run times of female collegiate track athletes

Context: Pseudoephedrine (PSE) is an over-the-counter decongestant that might have ergogenic effects. The World Anti-Doping Agency has prohibited large doses (>150 μg/mL) of PSE, while the National College Athletic Association (NCAA) does not include it on their banned-substance list. Purpose: This study examined the effect of body-weight dosing of PSE on 800-m-run times of NCAA female runners. Methods: Fifteen NCAA female track athletes volunteered to participate in the randomized, double-blind, crossover design. Participants were given 2.5 mg/kg PSE or placebo in trials separated by a week. Ninety minutes postingestion, participants completed an 800-m individual time trial on an indoor track. Finishing time was recorded with an automated video timing device. Heart rate and anxiety state scores were recorded immediately after each trial. Results: Fourteen runners completed both trials, and 1 was an outlier: N = 13. Despite the dose being well above normal therapeutic levels (144 ± 17 mg), there was no si...