Islet Allotransplantation in the Bone Marrow of Patients With Type 1 Diabetes: A Pilot Randomized Trial

Paola Maffi,Rita Nano,Paolo Monti,Raffaella Melzi,Valeria Sordi,Alessia Mercalli,Silvia Pellegrini,Maurilio Ponzoni,Jacopo Peccatori,Carlo Messina,Angela Nocco,Massimo Cardillo,Marina Scavini,P. Magistretti,Claudio Doglioni,Fabio Ciceri,Stef J. Bloem,Bart O. Roep,Antonio Secchi,Lorenzo Piemonti

Islet Allotransplantation in the Bone Marrow of Patients With Type 1 Diabetes: A Pilot Randomized Trial

2018

Background.Results in murine and nonhuman primate suggested that the bone marrow (BM) might be an alternative site for pancreatic islet transplantation.Methods.We report the results of 2 clinical studies in patients with type 1 diabetes receiving an intra-BM allogeneic islet transplantation: a feasi

Keywords:

Bone marrow
Randomized controlled trial
Immunology
General surgery
Type 1 diabetes
Allotransplantation
Diabetes mellitus
Medicine
Islet
nonhuman primate
Internal medicine
Oncology
Transplantation

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