Effect of cis-platinum(II)diamminedichloride and gallium nitrate on the ability of spleen cells to induce a graft-versus-host reaction.

SummaryWe used the recently described rat popliteal node assay, a sensitive in vivo test of thymic-dependent lymphocyte funciton, to measure the effects of cis-platinum (II) diamminedichloride and gallium nitrate on the ability of spleen cells from treated parental rats to induce a graft-versus-host reaction in hybrid recipients. In doses sufficient to cause morbidity and weight loss of the donor rats, no significant suppression of the reaction could be demonstrated.