Diagnosing Drug Resistance in Low-Resource Settings: Practical Approaches

are focal nodes in biosynthetic network of virulent lipids, inhibitors directed against these proteins provide a unique multi-pronged approach of simultaneously disrupting several pathways in lipid metabolism. Our study illustrate how obligate pathogens like Mtb have evolved such novel themes of functional versatility to generate unusual metabolites. We also reveal possible evolutionary path traced by FAALs from omnipresent fatty acyl CoA ligases. Furthermore, our study also provide credence to the ‘systems pharmacology’ approach for drug discovery.