Influence of chlortetracycline and neomycin on digestion and absorption of fat in rats.

Effects of chlortetracycline (CTC) and neomycin on the rate of lipolysis and alimentary lipemia in rats, after the introduction of 1 ml of olive oil or a suspension of 1/10 of the ld50 doses of antibiotics in oil, were determined after 1 and 3 hr. Presence of CTC or neomycin did not affect the rate of gastric emptying. A similar finding was obtained concerning the amount of fat left in the intestine after these periods. In the presence of CTC the lipolysis was significantly inhibited after 1 as well as after 3 hr; alimentary lipemia was slowed down in the 1st hr, and after 3 hr a return to normal levels was achieved. Administration of neomycin did not influence the rate of lipolysis, but was followed by a lower level of alimentary lipemia not only after 1 hr but also after 3 hr.