Organ involvement in immunoglobulin a vasculitis (Henoch-Shönlein purpura) children: Relation to immune profile

Abstract Aim of the work The aim of this work was to study the pattern of immunoglobulin A (IgA) vasculitis organ involvement distribution in a cohort of patients in Turkey and to determine the relation to immune profile biomarkers. Patients and methods Two hundred and sixteen IgA vasculitis children were evaluated. Demographic characteristics, organ involvements, laboratory findings and immunological factors accompanying joint, gastrointestinal tract (GIT) and renal involvements were investigated through the data retrieved from patient files and hospital records. Results All patients had palpable purpuric skin involvement, GIT involvement was present in 37%, joint involvement in 55.4% and renal in 31.5%. Leucocytosis was present in 46.3%, thrombocytosis in 20.4%, elevated erythrocyte sedimentation rate in 63%, positive C-reactive protein in 37%, antistroptolysin-O titre in 33.3%, high IgA in 13% and IgE in 24.1%. Patients with renal involvement had higher mean age and higher hemoglobin levels than those without (p  Conclusions Older age and GIT involvement in IgA vasculitis affect renal involvement and may lead to nephrotic-level proteinuria. In contrast, ANA, anti-dsDNA, RF, ANCA, factor XIII, fibrinogen and vWF levels were not related to organ involvement.