Ti3C2 MXene as a novel substrate provides rapid differentiation and quantitation of glycan isomers with LDI-MS

Here we report Ti3C2 MXene assisted LDI-LIFT-TOF/TOF for robust differentiation and relative quantitation of glycan isomers that differ in composition, connectivity and configuration. The improved sensitivity and background-free properties of this substrate combined with the special fragment profile produced by LDI-LIFT-TOF/TOF open a new door for nanomaterial assisted glycan structual analysis.