Bad Signs: Sickle-Cell Disease and Stroke

Johnny was a delightful little boy who was born with sickle-cell disease, an inherited genetic disorder that affects hemoglobin, a protein in the red blood cells responsible for transporting oxygen. Normal red blood cells are soft and round. In sickle-cell disease, the red blood cells are hard and sickle in shape. Consequently, they are likely to get stuck within blood vessels, causing severe pain and other medical complications. Specifically, sickle-cell disease is associated with increased incidence of vascular occlusions (pain crisis), cerebrovascular occlusions (stroke), infections, pulmonary difficulties, and organ damage. Some individuals with sickle-cell disease experience few complications, while others experience many.