Advances in Preaxial Polydactyly Genes

Preaxial polydactyltv(PPD)is one of the most frequently observed human limb developmental disorders.Shh ectopically expression and Lmbr1 mutation induce supernumerary digits.PPD genes have been mapped to a 450 kb region on chromosome 7q36.Previous pedigree studies shows that the long-range cisregulation for Shh in Lmbr1 play a key role in PPD. Key words: Preaxial polydactyly; Shh; Lmbr1; 7q36