Synthesis of (+)- and (−)-2-methylarachidonyl-2′-fluoroethylamide (O-689)
1997
Abstract The enantiomers of 2-methylarachidonyl-2′-fluoroethylamide, (+)- 4a (>98% ee) and (−)- 4b (98% ee), were synthesized from methyl arachidonate and were shown to be nonenantioselective in binding to the cannabinoid receptor (CB 1 ) and in the mouse tetrad tests.
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