Urinary Excretion of Uric Acid and Allantoin by the X-Irradiated-Adrenalectomized Rat.∗†

Summary1. X-irradiation of fasting rats with doses ranging between 150 and 1000 r caused an increased excretion of uric acid (75 to 206%) and allantoin (39 to 74%) during the first 24 hours. 2. Total purine excretion (sum of uric acid plus allantoin) tended to increase with increasing X-radiation dose. 3. Removal of adrenal glands reduced to a small extent the amount of total purine excreted but the magnitude of the increase due only to irradiation was the same in adrenalectomized and intact rats. 4. It is concluded that increased purine excretion following irradiation of the rat is not dependent on adrenal gland activity.