The Human Insulin Analogue Aspart Is Not the Almighty Solution for Insulin Allergy

Although human insulin is beneficial for most diabetic patients, some patients suffer from an allergy to exogenous insulin. Human insulin analogues, lispro or aspart, have been well tolerated in cases of insulin allergy. However, we report herein the first case of allergy to both lispro and aspart. A 53-year-old woman with a history of type 2 diabetes for the past 3 years consulted our hospital for management of uncontrolled diabetes. Her postprandial blood glucose level was 12.9 mmol/l, and her HbA1c level was 10.2%. She was initially treated with oral hypoglycemic agents (voglibose, glimepiride, metformin, and pioglitazone), which led to a decrease in …