A New Self-Fabrication of Large-Scale Deoxyribonucleic Acid Network on Mica Surfaces.

We have successfully fabricated large-scale deoxyribonucleic acid (DNA) networks on mica surfaces using a simple and easy fabrication method for the first time. Sample drops of poly(dA-dT)poly(dA-dT) which is a synthetic linear DNA were spotted on freshly cleaved mica and blown off with air. At low DNA concentrations, clusters of DNA molecules were separated from each other. However at high concentrations, substrates were covered with a two-dimensional DNA network measuring more than 12 mm laterally. The DNA network discovered in our study seems highly practical due to its simple and easy fabrication method and its length. We believe this DNA network has the potential to serve as a biomaterial for medical, engineering and environmental applications.