The Assessment of Some Metabolic Markers by Combination of Ursolic Acid Supplementation and Resistance Training in Young Older Obese Women

BACKGROUND Intensity resistance training and ursolic acid (UA) supplementation may be effective against metabolic disorders. INTRODUCTION In this study, we explored the impacts of a moderate-to-high intensity resistance circuit training (MHRCT) and UA supplementation to improve these pathological changes in young older obese women (women between the ages of 50 and 70). METHODS The study included Twenty-five young older women (age > 50 years and ≤70 years) with stage I-II obesity (BMI ≥ 30 and <40 kg/m2 ), received eight weeks placebo with MHRCT, and MHRCT with UA supplementation. UA or Placebo orally was ingested as a capsule three times per day for eight weeks. The following parameters were evaluated post- and preintervention. Data were analyzed using ANOVA with repeated measures. RESULTS Interleukin-15 (IL-15), Interleukin-6 (IL-6), Insulin, and HOMA-IR decreased significantly in the placebo and UA groups versus control, but the UA group significantly decreased in compared with the placebo (p<0.05). In turn, the BrainDerived Neurotrophic Factor (BDNF) and Irisin levels showed an increase significant in the placebo and UA groups versus control. However, the BDNF in UA group significantly increased in compared with the placebo (p < 0.05). CONCLUSION We demonstrated that applying resistance training can reverse the pathological changes that may occur with aging and sedentary life style. Our results showed that UA can enhance the effects of this type of exercise. Therefore, a combination of resistance training program and UA supplementation may be considered as a novel and influential intervention to metabolic derangements and also decrease the burden associated with this condition.