Paget phenomenon of the vulva with histopathological features of high-grade urothelial carcinoma (transitional cell carcinoma)

Extra-mammary Paget's disease (EMPD) and ‘Paget phenomenon’ commonly affect the genital and perianal areas of elderly persons. EMPD is a cutaneous adnexal adenocarcinoma arising within the epidermis. In contrast, Paget phenomenon is an involvement of the skin by a non-cutaneous neoplasm and can be caused either by direct extension or by epidermotropic metastasis of the neoplastic cells. The most common cause of Paget phenomenon is an anal or rectal adenocarcinoma, and the second most common cause [...]