A Graphenic and Potentiometric Sensor for Monitoring the Growth of Bacterial Biofilms
2020
Biofilm development on surfaces represents one of the most challenging issues in the
medical field. The irreversibility of this process, and the characteristics of the biofilm, make biofilm
associated infections difficult to treat and prone to relapse. Thanks to the short response time, low-
cost, easy fabrication and potential for miniaturization, electrochemical sensors are expected to play
an important role in monitoring biofilm formation. Here, we describe the use of a potentiometric
sensor based on functionalized reduced graphene oxide for monitoring the formation and growth of
biofilms from three bacterial species (Escherichia coli, Pseudomonas aeruginosa and
Staphylococcus aureus) in liquid and semisolid culture media. The Open Circuit Potential (OCP)
between an Ag/AgCl pseudo reference electrode and a working electrode, both screen-printed on a
flexible polyethylene terephthalate film, was measured during the growth of bacteria. The OCP
decreased over time as bacteria grew on the sensor surface exhibiting a negative correlation
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