Relationship between global indices of reactivity, electrodonating and electroaccepting powers, and the hammet constant in isatoic anhydride derivatives

The possible correlation between Hammett’s constant (σ p), a characteristic parameter of functional groups with electrodonating or electroaccepting properties, and two indices of global reactivity were calculated in the gas phase. Parameters associated to a set of 22 structural variants of isatoic anhydride (2H–3, 1–benzoxazin–2,4(1H)–dione, ISA), replaced with diverse functional groups, were explored applying linear and quadratic statistical models for numerical analysis of the results.