Advances in molecular genetics of familial arrhythmogenic right ventricular cardiomyopathy

Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a predominant type of autosomal dominant inherited disease. Typical pathological features of ARVC include cardiomyocyte atrophy and fibrofatty replacement; clinical manifestation of ARVC is ventricular tachycardia with left bundle branch block. Researchers have developed a number of studies on the mechanism underlying ARVC, and new advances have been made in the study on pathogenic genes. In this review, the gene mutations and associated genetic pathogenesis of ARVC will be elaborated. Key words: Arrhythmogenic right ventricular cardiomyopathy; Gene mutations; Pathogenesis