[Association of adiponectin gene polymorphisms +45T/G with gestational diabetes mellitus and neonate birth weight].

Objective To determine the association of single-nucleotide polymorphisms (SNPs) +45T/G of adiponectin gene with gestational diabetes mellitus (GDM) and neonate birth weight. Methods A total of 264 GDM and 272 pregnant women with normal glucose (NG) were enrolled.DNA was successfully extracted from peripheral blood leucocyte samples.And SNPs+45T/G of adiponectin gene were examined.We also analyzed differences in the genotypic distribution and allelic frequencies in SNP+45T/G of adiponectin gene among GDM group with different neonate birth weights. Results There was no significant difference between two groups with respects to SNP+45T/G polymorphisms of adiponectin gene (P>0.05).But significant genotypic difference existed in SNP+45T/G among three GDM groups with different birth weights.Frequencies of T allele were significantly higher in the GDM group with higher birth weight, 68.75% in GDM group with macrosomia and 72.86% in GDM group with 3000-4000 g birth weight (both P<0.01).And there was no significant difference in SNP+45T/G polymorphisms of adiponectin gene between GDM women and NG group with macrosomia. Conclusion SNP+45T/G polymorphisms of adiponectin gene are not associated with GDM.However, SNP+45T/G polymorphisms of adiponectin gene of GDM women are closely associated with neonate birth weigh.The G/T polymorphisms of SNP+45 of adiponectin are not obviously associated with a higher occurrence of macrosomia in GDM women. Key words: Diabetesmellitus; Gestational; Adiponectin; Geneticpolymorphisms; Birthweight