HPV16 and 18 genome amplification show different E4-dependence, with 16E4 enhancing E1 nuclear accumulation and replicative efficiency via its cell cycle arrest and kinase activation functions

Nagayasu Egawa,Qian Wang,Heather Griffin,Isao Murakami,Deborah J. Jackson,Radma Mahmood,John Doorbar

HPV16 and 18 genome amplification show different E4-dependence, with 16E4 enhancing E1 nuclear accumulation and replicative efficiency via its cell cycle arrest and kinase activation functions

2017

Nagayasu Egawa
Qian Wang
Heather Griffin
Isao Murakami
Deborah J. Jackson
Radma Mahmood
John Doorbar

The work was supported by the UK Medical Research Council (grant ref. MC_PC_13050 / Molecular biology of human papilloma virus infection to JD, http://gtr.rcuk.ac.uk/ project/A691 306C-DAA9- 4078-B5D E- 2096CF3C8A18).

Keywords:

Virology
Medical research
Human papilloma virus infection
Genome
Biology
Cell cycle checkpoint
Kinase
Molecular biology
Viral life cycle
Cell
Cell growth
Wild type
Viral replication

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