Comment on "Inhibition of Hepatitis B Virus Replication by APOBEC3G"

The cytidine deaminase APOBEC3G (A3G) was recently identified as a natural resistance gene that restricts efficient propagation of human immunodeficiency virus and other retroviruses. The enzyme induces massive cytidine to uridine (C→ U) deamination of single-stranded retroviral DNA, resulting in