Insulin Analogues — Potentials for Improving Diabetes Treatment

Despite many years of clinical experimentation with commercially available short-, intermediate-, and long-acting insulin preparations, good metabolic control is still difficult to attain in a large proportion of insulin-dependent diabetics. Two basic problems emerge from the clinical studies: 1. the rate of insulin uptake after sub-cutaneous injection of conventional short-acting preparations is too slow; and 2. the pharmacokinetics of intermediate- and long-acting preparations vary too much.