DifferentialFc-ReceptorEngagementDrivesanAnti- tumor Vaccinal Effect
2015
Passively administered anti-tumor monoclonal anti-bodies (mAbs) rapidly kill tumor targets via FcgR-mediated cytotoxicity (ADCC), a short-term process.However, anti-tumor mAb treatment can also induceavaccinaleffect,inwhichmAb-mediatedtumordeathinduces a long-term anti-tumor cellular immuneresponse. To determine how such responses aregenerated, we utilized a murine model of an anti-tu-mor vaccinal effect against a model neoantigen. Wedemonstrate that FcgR expression by CD11c
Keywords:
- Correction
- Source
- Cite
- Save
- Machine Reading By IdeaReader
44
References
0
Citations
NaN
KQI