Tandem synthesis of highly functionalized 1,2,3-benzotriazines from isocyanides, aniline and dialkyl azadicarboxylate via Cu-catalyzed intramolecular C-H activation reactions

Abstract A class of substituted 1,2,3-benzotriazines are obtained in tandem mode reaction by means of Cu-catalyzed intramolecular C-H activation of aniline, isocyanides and dialkyl azadicarboxylate in acetonitrile at room temperature in good yields. The speed and ease of carrying out this three-component reaction under mild one-pot conditions with available materials, without using column chromatography, make it a method of choice to synthesize substituted 1,2,3-benzotriazines derivatives.