Antibiotics use in perioperative period of type I incision operations by MTP mode: a comparative study.

OBJECTIVE To evaluate rational use of antibiotics for typeⅠ incision operations including thyroid surgery,breast surgery and hernioplasty in perioperative period by monitoring-training-planning(MTP)intervention model.METHODS The data of medications of two patients groups in two fertiary care hospitals in Mar or Sep 2008 were collected(totally 330 cases)and compared.Cases in March of intervention group were inquired as the baseline survey,and then preceded MTP mode of interventions.While non-intervention group cases in March were also inquired as the baseline survey,but subsequently were not interfered with the MTP mode.RESULTS In intervention group,compared pre-nd post-intervention,the percentage of antibiotics use was decreased from 100.00% to 60.47%(P0.05).The first three antibiotics used were changed from cefathiamidine,penicillin sodium and furbucillin to lincomycin,cefazolin and cefradine.The average hospitalization days decreased from 9.45d to 8.93d.The former average drug expenses were 2433.05 yuan,while after intervention obviously declined to 1732.22 yuan(P0.05).The average cost of antibiotics decreased from 988.17 yuan to 81.25 yuan(P0.05).In non-intervention group,compared Pre-and post-intervention,the percentage of antibiotics use was decreased from 100.00% to 98.86%(P0.05).The first three antibiotics used were changed from cefoperazone/sulbactam,amikacin,and cefoperazone to levofloxacin,cefoperazone and isepamicin.The average hospitalization days increased from 11.61d to 13.02d.The average drug expenses were 2860.87 yuan,and declined to 2636.89 yuan after intervention(P0.05).The average cost of antibiotics increased from 1067.43 yuan to 1220.17 yuan(P0.05).CONCLUSIONS The intervention-control study shows that MTP intervention mode is feasible and effective,which can significantly reduce antibiotic use,improve the rational use of antibiotics,reduce drug costs and well promote the safe,effective and economical clinical application of antibiotics.