In vivo release of lymphokines in different strains of mice

Abstract Attempts were made to induce the two lymphokines, migration inhibitory factor and interferon II, in vivo with antigens from the tubercle bacillus. Of 11 strains of mice assayed, marked variations occurred in the capacity to release these lymphokines. This capacity to respond, however, was altered by the mode of presentation of the antigen. The migration inhibitory factor and interferon II appeared together in the responding strains, and both were absent in the nonresponding strains.