Study on leuprorelin acetate in treatment of uterine adenomyosis with infertility

Objective To study clinical efficacy of leuprorelin acetate in treatment of uterine adenomyosis with infertility. Methods From January 1,2011 to March 31,2012,166 cycles in 166 infertile patients combined with uterine adenomyosis undergoing in vitro fertilization embryo transplant (IVF-ET) with long protocol ovum induction by leuprorelin acetate in centre of medical reproduction,ningbo women and children's hospital were studied retrospectively.In the mean time,200 cycles in 200 infertile patients with tubal factors were enrolled as control group.The volume of uterus and outcome of IVF-ET were compared and studied between two groups. Results (1) Volume of uterus:in adenomyosis group,after 2-6 cycles of injecting leuprorelin acetate (3.75 mg/28 days),the mean uterine volume was shrinked from (180±73) cm3to (86±67) cm3 (P P > 0.05). (3) In adenomyosis group,the rate of fertilization,two pronuclear (2PN) and superior embryo were 67.2% (319/475),60.8% (289/475) and 52.9% (162/ 306) in patients with failed pregnancy and 74.2% (423/570),67.7% (386/570) and 62.1% (256/412) in patients with successful pregnancy after IVF-ET,which reached significant difference ( P < 0.05). Conclusion Leuprorelin acetate could improve volume of uterine adenomyosis and outcome of pregnancy in patients undergoing IVF-ET. Key words: Endometriosis; Infertility,female; Leuprolide; Microspheres; Fertilization in vitro; Embryo transfer; Treatment outcome