QOS-48PREVALENCE AND RISK FACTORS OF EARLY ENDOCRINE DISORDERS IN CHILDHOOD BRAIN TUMOR SURVIVORS: A NATIONWIDE MULTICENTER STUDY

QOS-48. PREVALENCE AND RISK FACTORS OF EARLY ENDOCRINE DISORDERS IN CHILDHOOD BRAIN TUMOR SURVIVORS: A NATIONWIDE MULTICENTER STUDY Sarah Clement1,2, Antoinette Schouten-van Meeteren1, Annemieke Boot3, Hedy Claahsen-vd Grinten4, Bernd Granzen5, Sen Han6, Geert Janssens4, Erna Michiels7, Paul Van Trotsenburg2, Peter Vandertop2, Dannis Van Vuurden8, Leontien Kremer2, Huib Caron2, and Hanneke Van Santen1; Wilhelmina Children’s Hospital UMCU, Utrecht, The Netherlands; Emma Children’s Hospital AMC, Amsterdam, The Netherlands; University Medical Centre Groningen, Groningen, The Netherlands; Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands; Maastricht University Medical Centre, Maastricht, The Netherlands; University Medical Centre Utrecht, Utrecht, The Netherlands; Sophia Children’s Hospital Erasmus MC, Rotterdam, The Netherlands; Vrije Universiteit Medical Centre, Amsterdam, The Netherlands PURPOSE: To evaluate the prevalence of, and risk factors for early endocrine disorders in childhood brain tumor survivors (CBTS). PATIENTS AND METHODS: This nationwide study cohort consisted of 718 CBTS diagnosed between 2002 and 2012, surviving . 2 years after diagnosis. Exlusion of patients with craniopharyngeoma or a pituitary gland tumor. Results of endocrine investigations, performed atdiagnosis andduring follow-up, were collected from patient charts. Multivariable logistic regression was used to study associations between demographic, and tumorand treatment-related variables, and the prevalence of early endocrine disorders. RESULTS: After a median follow-up of 6.6 years, 178 CBTS (24.8%) were diagnosed with an endocrine disorder. A total of 159 CBTS (22.1%) presented with at least one endocrine disorder within the first 5 years after diagnosis. Most common endocrine disorders were: growth hormone deficiency (12.5%), thyroid stimulating hormone deficiency (9.2%), precocious puberty (6.7%) and thyroidal hypothyroidism (5.8%). The riskof hypothalamic-pituitary dysfunction (N 1⁄4 138) wasassociated with radiotherapy (RT) (OR 15.74 (95% CI8.72-28.42)), younger age at diagnosis (OR 1.09 (95% CI: 1.04-1.14)), advanced follow-up time (OR 1.10 (95% CI: 1.02-1.18)), hydrocephalus at diagnosis (OR 1.77 (95% CI: 1.09-2.88)), suprasellar (OR 34.18 (95% CI: 14.74-79.29)) and infratentorial tumor site (OR 2.65 (95% CI 1.48-4.74). CONCLUSION: The prevalence of early endocrine disorders among CBTS is high. The observation that 22.1% of the CBTS developed at least one endocrine disorder within 5 years after diagnosis stresses the importance of early and regularly assessment of endocrine function in CBTS at risk for endocrine damage. Neuro-Oncology 18:iii145–iii158, 2016. doi:10.1093/neuonc/now081.48 #The Author(s) 2016. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.