Лікування поршень сну, що асоційовані з тривогою, у пацієнтів з розсіяним склерозом

Sleep disorders (SD) have a crucial impact on enhancement of disability and decreasing quality of life alongside with motor, cognitive and psycho-emotional disorders in patients suffering from multiple sclerosis (MS). The aim of our study was to determine efficiency of treatment of MS patients suffering from sleep disorders associated with anxiety and evaluation of possible medication’s effect on fatigue severity, cognitive impairment and asthenia features among participants. Twenty patients enrolled in the current study were suffering from MS with relapsing-remitting and secondary-progressive types (mean age 43,7 ± 8,9; disease duration 11,3 ± 7,6) and had sleep disorders of different severity associated with anxiety. The following questionnaires were applied in the study: The Pittsburgh Sleep Quality Index (PSQI), Hamilton Anxiety Rating Scale (HAM-A), The Montreal Cognitive Assessment (MoCA), Modified Fatigue Impact Scale (MFIS), Asthenic State Scale (ШАС). According to results of the Pittsburgh Sleep Quality Index 10% of participants had mild sleep disorders, 35% had moderate and 55% had severe. Based on HAM-A results 30% had mild, 25% had mild and 45% had severe anxiety. A drug Valeo-Dorm Duo (kryzin, melatonin) was applied for treatment. The dynamics of sleep quality, anxiety, cognitive impairment and asthenia indicators during the treatment were evaluated with the use of corresponding scales. A significant improvement of sleep quality was found in 70% of patients after treatment, as well as decreased level of anxiety in 45% to mild and in 55% to moderate according to HAM-A scale. Applying of Valeo-Dorm Duo proved to be effective in cases of treatment of patients suffering from a combination of sleep disorders with anxiety. It prompted sleep normalization and decreasing of anxiety and asthenia symptoms, thus the treatment improved quality of life of these patients.