Fusion protein molecules and method of use

The present invention provides compositions of fusion molecules comprising a cytokine moiety and a targeting moiety. The cytokine moiety comprises one or more cytokines. The targeting moiety comprises one or more ligands. Each ligand is a peptide, a protein, or a small m olecule that recognizes a receptor on the target, such as but not limited to cells or viral particles. The targeting moiety targets the fusion molecules to the site of the targets and the cytokine moiety exerts its function at the site of the target, thereby resulting in enhanced activity of the cytokine. Also provided are uses of said compositions for treating diseases, such as but not limited to cancers and diseases resulted from viral infection.