Evaluation of anti-diabetic effect and gall bladder function with 2-thio-5-thiomethyl substituted imidazoles as TGR5 receptor agonists

Xuqing Zhang,Zhihua Sui,Jack Kauffman,Cuifen Hou,Cailin Chen,Fuyong Du,Thomas Kirchner,Yin Liang,Dana L. Johnson,William V. Murray,Keith T. Demarest

Evaluation of anti-diabetic effect and gall bladder function with 2-thio-5-thiomethyl substituted imidazoles as TGR5 receptor agonists

2017

Xuqing Zhang
Zhihua Sui
Jack Kauffman
Cuifen Hou
Cailin Chen
Fuyong Du
Thomas Kirchner
Yin Liang
Dana L. Johnson
William V. Murray
Keith T. Demarest

Abstract A novel series of 2-thio-5-thiomethyl substituted imidazoles was discovered to be potent TGR5 agonists that possessed glucose-lowering effects while inhibiting gall bladder emptying in mice.

Keywords:

Biochemistry
Bladder emptying
G protein-coupled bile acid receptor
Gall
Thio-
Chemistry
Receptor
Gallbladder Emptying
Cell culture
bladder function

Correction
Source
Cite
Save
Machine Reading By IdeaReader

References

Citations