Omega-3 fatty acid protects against chemical induced liver injury- an experimental study

INTRODUCTION: The mainstream detoxification of chemical agents is carried out in liver which is chief organ of body. Omega-3 is belonging to family of polyunsaturated fatty acids which has several beneficial effects on metabolism and inflammation. OBJECTIVE: To assess to hepatoprotective effects of the Ω- 3-FA on carbon tetra chloride induced liver injury in laboratory animals at animal house. METHODOLOGY: After ethical review committee approval this study was performed at the Department of Anatomy and Pathology, Bhitai Dental and Medical College and Animal house of Sindh Agriculture University Tando Jam. 80 Wistar albino rats were selected and randomly divided into 4 groups and drugs were given for allocated time. Blood sampling, biochemical and histopathological analysis were carried out. RESULTS: The Ω- 3-FA and silymarin demonstrated protective effects against the CCl4 induced liver injury. Group C and D which were treated with the Ω- 3-FA and silymarin revealed significant amelioration of the liver function tests (p<0.05). CONCLUSION: The rat models showed tremendous benefits of omega-3 on liver due to carbon tetrachloride induced damage. KEY WORDS: Omega-3, Carbon tetrachloride, Hepatocellular injury