Rapid Detection of SNP (c.309T>G) in the MDM2 Gene by the Duplex SmartAmp Method
2013
Background
Genetic polymorphisms in the human MDM2 gene are suggested to be a tumor susceptibility marker and a prognostic factor for cancer. It has been reported that a single nucleotide polymorphism (SNP) c.309T>G in the MDM2 gene attenuates the tumor suppressor activity of p53 and accelerates tumor formation in humans.
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