Retinal lipid and glucose metabolism dictates angiogenesis through the lipid sensor Ffar1

Jean-Sebastien Joyal,Ye Sun,Marin L. Gantner,Zhuo Shao,Lucy P Evans,Nicholas Saba,Thomas Fredrick,Samuel B. Burnim,Jin Sung Kim,Gauri Patel,Aimee M. Juan,Christian G. Hurst,Colman J. Hatton,Zhenghao Cui,Kerry A. Pierce,Patrick Bherer,Edith Aguilar,Michael B. Powner,Kristis Vevis,Michel Boisvert,Zhongjie Fu,Emile Levy,Marcus Fruttiger,Alan B. Packard,Flavio Rezende,Bruno Maranda,Przemyslaw Sapieha,Jing Chen,Martin Friedlander,Clary B. Clish,Lois E. H. Smith

Retinal lipid and glucose metabolism dictates angiogenesis through the lipid sensor Ffar1

2016

Retinal neovascularization, as occurs in age-related macular degeneration, may result from an increase in VEGFA levels due to dysregulated lipid and glucose metabolism within photoreceptors.

Keywords:

Free fatty acid receptor 1
Macular degeneration
Angiogenesis
Retina
Carbohydrate metabolism
Vascular endothelial growth factor A
Retinal
Lipid metabolism
Endocrinology
Medicine
Internal medicine

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