Asymmetric total syntheses of (−)-tylophorine via the highly enantioselective intramolecular double michael reaction

Abstract Asymmetric total synthesis of (−)-tylophorine ( 2 ) was achieved with a high enantioselectivity through the intramolecular double Michael reaction of the α, β-unsaturated ester ( 8 ) having a novel chiral auxiliary with tert.-butyldimethylsilyl trifluoromethanesulfonate and Et 3 N.