Relationship between the expression levels of PAPP-A metalloproteinase and growth and transcriptional factors in endometrial cancer

We have examined for the first time the relationship between the expression of PAPP-A metalloproteinase and insulin-like growth factors (IGF-I, IGF-II, VEGF) and transcription factors (NF-κB, HIF-1) playing an important role in pathogenesis of cancer. We also demonstrated a positive association between the level of PAPP-A metalloproteinase and the level of growth (VEGF and IGF-I) and transcription factors (NF-κB p50, NF-κB p65, HIF-1α). The current findings suggest an important role of PAPP-A in regulation of bioavailability of IGF-I, VEGF, activated forms of NF-κB, and α-subunits of HIF-1 in endometrial tumors.