Advances in Research of p185 Protein and Its Antibodies .

p185 neu/c erbB 2 is a receptor tyrosine kinase . Its overexpressed in some adenocarcinomas, such as breast cancer and ovary cancer. It not only plays an important prognostic role, but also acts as a therapeutic target in breast cancer. Its function in signal tranduction is described. The protein engineering of antibodies against p185 and their application in cancer therapy is also discussed.