The comparison of Isth criteria for disseminated intravascular coagulation (DIC) Scale, Padua Scale, D-Dimer and fibrinogen like the best predictor of thrombosis in COVID-19 pneumonia

Background : Coagulation disturbances in COVID-19 pneumonia patients is already a well-known fact, but what marker can really reflect the disease progression is still unknown. Aims : The aim was to estimate the diagnostic and prognostic role of different coagulation markers and scales in hospitalized patients with confirmed COVID-19 pneumonia. Methods : The main group was 53 patients (age -59 (52;65), men -22 (41.5%)) with COVID-19 pneumonia, divided into 3 subgroups: subgroup 1 -36 patients with moderate COVID-19 pneumonia, subgroup 2 -12 patients with severe COVID-19 pneumonia, subgroup 3 -5 patients with critical COVID-19 pneumonia. General clinical analysis, blood coagulation test, determination of D-dimer and fibrinogen, ISTH Criteria for DIC, Padua Scale count were performed at admission before starting of antibacterial and anticoagulant treatment. Results : Individual analysis showed that 28 patients from group 2 and 3 had progression of COVID-19 pneumonia in dynamic due to thrombosis, which was manifested with increased respiratory failure. Conclusions : The ROC-analysis showed that ISTH Criteria DIC, Padua scale and D-dimer can really reflect the severity of COVID-19 pneumonia and predict the prognosis of the disease. 1) the best parameter for thrombosis prediction in hospitalized patients with COVID-19 is ISTH Criteria DIC;2) Increasing of ISTH Criteria DIC score at admission can reflect the risk of severe systemic coagulation disturbances which play a great role in the progression of disease.