Anticancer Anthrapyrazoles. Improved Syntheses of Clinical Agents CI-937, CI-941, and Piroxantrone Hydrochloride.

Vladimir Genukh Beylin,Norman L. Colbry,O. P. Goel,Jerome E. Haky,D. R. Johnson,Judith L. Johnson,Gerald D. Kanter,Robert L. Leeds,Boguslawa Leja,Edward P. Lewis,Christopher D. Rithner,H. D. Hollis Showalter,Anthony D. Sercel,W. R. Turner,Susan E. Uhlendorf

Anticancer Anthrapyrazoles. Improved Syntheses of Clinical Agents CI-937, CI-941, and Piroxantrone Hydrochloride.

1989

Vladimir Genukh Beylin
Norman L. Colbry
O. P. Goel
Jerome E. Haky
D. R. Johnson
Judith L. Johnson
Gerald D. Kanter
Robert L. Leeds
Boguslawa Leja
Edward P. Lewis
Christopher D. Rithner
H. D. Hollis Showalter
Anthony D. Sercel
W. R. Turner
Susan E. Uhlendorf

Improved processes for the synthesis of bulk quantities of the anthrapyrazole clinical agents CI-937, CI-941, and piroxantrone hydrochloride are reported. Reported also are detailed analytical and spectroscopic data for these agents and intermediates of the synthetic sequences.

Keywords:

Anthrapyrazoles
PIROXANTRONE HYDROCHLORIDE
Chemistry
Organic chemistry

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