Multilayered Particles Based on Biopolyelectrolytes as Potential Peptide Delivery Systems

A series of amphiphilic charged copolymers of amino acids is synthesized, and their binding to cationic and anionic peptides is studied. The resulting interpolyelectrolyte complexes are additionally stabilized by cationic/anionic polysaccharides using surface layering. The positive effect of coatings on the release rate of peptides and decrease in the cytotoxicity and increase in the stability of the resulting peptide delivery systems in biological media is shown.