Hepatoprotective Xanthones from the Aerial Parts of Pyrethrum tatsienense

A new xanthone, named 1,3,5,9-tetrahydroxy-2-prenyl-4-(3′′ -hydroxy-3′′ -methylbutanoyl)-6,6- dimethylpyranoxanthen-10-one (1), along with five known xanthone derivatives (2–6), were isolated from Pyrethrum tatsienense for the first time. Their structures were elucidated on the basis of extensive spectroscopic analysis and references. Compounds 1–6 were screened for their hepatoprotective activities by MTT assay against D-galactosamine induced toxicities in HL-7702 cells, which revealed that compounds 1, 4, and 5 exhibited moderate hepatoprotective activities.