The efficacy of dipyridamole combined with narceine in the protection of internal arteriovenous fistula

Objective To investigate an effective method for protection of arteriovenous fistula ( AVF ) in patients on maintenance hemodialysis.Methods 85 patients on maintenance hemodialysis who required surgery for arteriovenous fistula were randomly divided into dipyridamole and narceine group ( n =43 ) and aspirin group ( n =42 ).The incidence rates of vascular stenosis, occlusion of blood vessels, vascular ectasia, and vascular sclerosis were observed.Volume of blood flow to fistula,bleeding time after needle removal,dynamic venous pressure,and KT/V values?? were compared.Results In dipyridamole and narceine group,occlusion of blood vessels occurred in one patient ( 2.33％ ) and vascular stenosis developed in 6 ( 13.95％ ); whereas in the control group,occlusion of blood vessels occurred in 8 patients ( 19.05％ ) and vascular stenosis developed in 15 ( 35.71％ ),with a significant statistical difference ( P＜ 0.05 ).There were significant differences in volume of blood flow to fistula,bleeding time after needle removal,dynamic venous pressure,and KT/V ( P＜ 0.05 ).Conclusions Dipyridamole combined with narceine can effectively protect internal arteriovenous fistula and prolong its lifespan. Key words: Dipyridamole;  Narceine;  Arteriovenous fistual