Mechanosensitive transcriptional coactivators MRTF-A and YAP/TAZ regulate nucleus pulposus cell phenotype through cell shape

Bailey V. Fearing,Liufang Jing,Marcos N. Barcellona,Savannah Est Witte,Jacob M. Buchowski,Lukas P. Zebala,Michael P. Kelly,Scott J. Luhmann,Munish C. Gupta,Amit Pathak,Lori A. Setton

Mechanosensitive transcriptional coactivators MRTF-A and YAP/TAZ regulate nucleus pulposus cell phenotype through cell shape

2019

Bailey V. Fearing
Liufang Jing
Marcos N. Barcellona
Savannah Est Witte
Jacob M. Buchowski
Lukas P. Zebala
Michael P. Kelly
Scott J. Luhmann
Munish C. Gupta
Amit Pathak
Lori A. Setton

Cells of the adult nucleus pulposus (NP) are critically important in maintaining overall disc health and function. NP cells reside in a soft, gelatinous matrix that dehydrates and becomes increasin...

Keywords:

Mechanosensitive channels
Actin
Nucleus
Cell biology
Intervertebral disc
Internal medicine
Endocrinology
Mechanotransduction
Phenotype
Biology
Cell
gelatinous matrix
cell phenotype
cell shape

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