Efek Antiagregasi Platelet Ekstrak Etanol Buah Mengkudu (Morinda Citrifolia L.), Rimpang Jahe Merah (Zingiber Officinale Var. Sunti Val.) Dan Kombinasinya Pada Mencit Jantan Galur Swiss Webster

Antiplatelet aggregation effect of noni fruits (Morinda citrifolia L.) and ginger (Zingiber officinale var. Sunti Val.) ethanol extract and its combination has been investigated in Swiss Webster mice. The test substances were given orally during the period of 28 days. Antiplatelet aggregation effect was tested by measuring bleeding time, coagulation time, and decreasing plasma absorbance to observe platelet aggregation activity before and after addition of ADP as platelet aggregation inducer. Based on the inhibition of  plasma absorbance decrease, noni fruits extract at a dose of 100 mg/kg body weight, ginger extract at a dose of 50 mg/kg body weight, combination of noni fruits at a dose of 100 mg/kg body weigfht  and ginger extract at dose of 50 mg/kg body weight as well as combination of each 50 and 25 mg/kg body showed the effect of  platelet aggregation inhibition of  66.67 ± 11.79% (p=0.028); 72.67 ± 18.62% (p=0.020); 63.00 ± 18.27% (p=0.033); and 77.14 ± 19.24% (p=0.016) respectively. The test substances above increased bleeding time of  422.83 ± 42.36% (p<0.001); 409.40 ± 190.69% (p=0.009); 552.03 ± 182.23% (p= 0.003); 441.67 ± 209.46% (p=0.010) respectively and increased coagulation time  of  33.52 ± 22.55% (p=0.049); 48.56 ± 29.26% (p=0.035); 39.40 ± 18.71% (p=0.017) and  58.42 ± 25.85% (p=0.010) respectively. There were no significantly differences among the combination extract of  1 dosage each ; of  ½ dosage each; and  single dosage of the extract  in increasing bleeding time, coagulation time, and inhibition of platelet aggregation.