Discovery of 5-HT6 receptor ligands based on virtual HTS

Stefan Tasler,Jürgen Kraus,A. Wuzik,Oliver Müller,Andrea Aschenbrenner,Elena Cubero,Rosalia Pascual,Jordi-Ramon Quintana-Ruiz,Alberto Dordal,Ramón Mercé,Xavier Codony

Discovery of 5-HT6 receptor ligands based on virtual HTS

2007

Stefan Tasler
Jürgen Kraus
A. Wuzik
Oliver Müller
Andrea Aschenbrenner
Elena Cubero
Rosalia Pascual
Jordi-Ramon Quintana-Ruiz
Alberto Dordal
Ramón Mercé
Xavier Codony

Abstract Based on a pharmacophore alignment on a 5-HT 6 ligand applying 4SCan ® technology, a new lead series was identified and further structurally investigated. K i s down to 8 nM were achieved.

Keywords:

Chemical synthesis
Virtual screening
Pharmacophore
G protein-coupled receptor
5-HT6 receptor
High-throughput screening
Biochemistry
Ligand
Chemistry
Stereochemistry
Molecular model

Correction
Source
Cite
Save
Machine Reading By IdeaReader

References

Citations